The Helltide is an endgame event in Diablo 4 where a certain region of the map becomes infested with special mobs for an hour. During the event, several chests spawn that drop a variety of legendaries, scaling with your World Tier. It's one of the best ways to get strong gear in the endgame.
Tortured Gifts of Mysteries are special chests that spawn in certain locations and don't appear on the world map. Multiple chests can spawn, and they refresh during the event. Chests refresh at the hour mark. So this does depend on when the event starts. Keep an eye on the clock to see if the chests will refresh during th event. Here's a list of the chest locations in each region of the map.
Above you can see the main part of Kehjistan. This area has the most mystery chest locations of anywhere on the map - it's an excellet place to farm the Helltide. Below is the southern part of the region.
As you progress into Diablo 4's endgame content, you'll be constantly upgrading your gear as better pieces drop. Your weapon provides a large portion of your overall damage, so using the best one available is imperative. However, when you get a new weapon, you'll also want to transfer your Legendary Aspects onto it, which can get expensive at higher levels.
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