The Diablo 4 Glyph mechanic is one of the game's more confusing, but it's important in terms of strengthening yourself in either Nightmare or Torment world tier, plus getting the most out of your Paragon board when you hit level 50. This is because each Glyph provide powerful bonus based on where you place it and what nodes you unlock in its radius.
If you're new to Diablo 4's endgame, then you might be curious about those newly unlocked Sacred and Unique items, that whole Helltide event, or where to find a world boss to take down. Otherwise, here's how to get Diablo 4 Glyphs, plus how to use and upgrade them for your Paragon board.
The best way to get Glyphs is by doing Nightmare Dungeons, since they often drop from elites, chests, and the final boss. You need to be world tier three in order to access Nightmare Dungeons, which means completing the campaign and beating the capstone dungeon in Kyovashad. Once complete, you can change your world tier at the statue in Kyovashad's main square.
Once you have a Glyph, you need to slot it into your Paragon board. You'll have to build a path to your first Glyph socket via unlocking nodes as you get Paragon points from levelling, and finally unlock the socket itself before you can place one in it.
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