Overview of This Study:

This market research study involved the extensive use of secondary sources, directories, and databases to identify and collect information useful for this technical, market-oriented, and financial study of the global in situ hybridization market.

In-depth interviews were conducted with various primary respondents, including key industry participants, subject-matter experts (SMEs), C-level executives of key market players, and industry consultants, among other experts, to obtain and verify critical qualitative and quantitative information and to assess market prospects. The size of the in situ hybridization market was estimated through various secondary research approaches and triangulated with inputs from primary research to arrive at the final market size.

Market Size Estimation:

The global size of the In Situ Hybridization market was estimated through multiple approaches. A detailed market estimation approach was followed to estimate and validate the value of the global ISH market and other dependent submarkets.. The research methodology and the market numbers were then validated from primaries.

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Challenge: Lack of skilled professionals

To conduct an ISH-based test, it is very crucial to understand the molecular information of a chromosome or a gene. In addition, the reluctance to move from manual operations to automation is another challenge for market growth. Many providers find it challenging to make the transition to IT-based approaches from manual or traditional methods, or may not prefer to make the shift at all. Thus, the shortage of skilled, well-trained, and technically knowledgeable laboratory technicians to conduct ISH-based diagnosis is limiting their overall adoption, particularly in emerging markets.

Opportunity: Untapped markets in developing countries

In developed countries, high-quality molecular diagnostic tests are readily available. However, in developing countries, the cost of these diagnostic technologies is very high, which often makes them unaffordable for a large part of the population. Moreover, the lack of a commercial market for diagnostic procedures has resulted in the availability of a small number of diagnostic tests in developing countries.

As a result, emerging markets such as India, China, Brazil, offer significant growth opportunities for MDx-based technology (including ISH) owing to the rising geriatric population, the growing prevalence of infectious diseases and various types of cancers, improving healthcare infrastructure, and increasing investments by respective government bodies and leading players in these countries.

Recent Developments:

# In 2020, RNAscope ISH Detection Kit (Bio-Techne) received CE-IVD approval for BOND-III platform (Leica Biosystems)

# In 2020, Creative Bioarray (US) launched 2019 Novel Coronavirus Detection FISH probes to detect viral particles in infected cells & tissues.

# In 2019, Roche launched VENTANA HER2 Dual ISH DNA Probe Cocktail assay

# In 2019, Roche provided its platform for integration with Bio-Techne’s RNAscope ISH assay.

# In 2019, Agilent Technologies, the National University of Singapore, and the National University Hospital set up Singapore’s first integrated R&D facility.

End Users:

Hospitals & diagnostic laboratories accounted for the fastest-growing end user segment of the ISH market

Based on the end user, the in situ hybridization market is segmented into hospital & diagnostic laboratories, academic & research institutes, CROs, and pharmaceutical & biotechnology companies. The hospital & diagnostic laboratories segment accounted for the largest share of the ISH market in 2019. This can be attributed to the increasing number of molecule-based screening, increasing number of specialty diagnostic tests performed in hospital laboratories, the rising number of in-house diagnostic procedures, and the rising trend of establishing in-house diagnostic capabilities in hospitals.

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North America accounted for the largest share of the ISH market

North America accounted for the largest share of the global market, followed by Europe. The large share of the North American region can be attributed to the presence of major players operating in the ISH market in the US, the rising incidence of cancer and infectious diseases, and the increasing adoption of CDx assay kits.

Key Players:

The prominent players operating in the in situ hybridization market are Abbott Laboratories (US), F. Hoffmann-La Roche Ltd (Switzerland), Agilent Technologies, Inc. (US), and Danaher Corporation (US).

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