CD Genomics, the world leading genomic sequencing company, is able to offer the genotyping of 11 all HLA loci, including HLA-A, B, C, DRB1, DRB3/4/5, DQA1, DQB1, DPA1, and DPB1 and deliver a thorough and detailed report.
As known, the HLA gene complex on human chromosome 6 is one of the most polymorphic regions in the human genome and contributes in a large part of the diversity of the immune system. Accurate typing of HLA genes with short-read sequencing data has historically been difficult due to the sequence similarity between the polymorphic alleles. Hence CD Genomics introduces an accurate and reliable HLA genotyping service, which uses NGS technology and amplification methods to address limitations of traditional Sanger sequencing assays.
HLA Genes have an important/integral role in the human adaptive immune system. For example, classical class I (HLA-A, -B, and -C) and class II (HLA-DR, -DP, and -DQ) HLA gene starts to function by presenting foreign antigens to T cells to trigger immune responses. Those HLA genes display amazing sequence diversity on human body. Let’s say it in another way, imagining there are >4,000 known alleles for the HLA-B gene alone. The genetic diversity in HLA genes in which different alleles have different efficiencies for presenting different antigens is believed to be a result of evolution conferring better population-level resistance against the wide range of different pathogens to which humans are exposed.
Since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. It is reported that HLA has been associated with more than hundreds of different diseases, including various autoimmune disorders, transplantation etc. However, although it plays an important role in human health, people do not routinely have their HLA genes typed. With the current trend toward precision medicine, knowing their HLA types will be crucial in early diagnosis and management of many diseases.
“CD Genomics HLA Typing can be done at different levels of resolution. We offer a worldwide service, with our high throughput service to process hundreds of samples at a time. We can only accept genomic DNA. Our aim is to deliver a high confidence and responsive service to our clients at realistic cost.”
About CD Genomics HLA typing Service
The service is offered for R&D / non-diagnostic purposes only and results must not be utilized to inform patient management decisions. It is featured with: first, comprehensive assay; second, unambiguous results; and third, sample-to-report solution. The service has complete workflow, covering from sample preparation, sequencing, data analysis, and reporting.
For more information, please visit https://www.cd-genomics.com/HLA-Typing.html
About CD Genomics
CD Genomics was established in 2004, the company is aiming at providing the research community with high quality Next Generation Sequencing, high throughput microarray services. Due to the demand for our services has being increased; CD Genomics has already updated its technology platform to mainstream NGS and microarray instruments.