The global empty capsules market is estimated to accumulate over US$ 3,122.5 million, in terms of value, by the end of 2027. Approval and launch of drugs and medications that are available in the form of capsules is expected to bolster the global empty capsule market growth over the forecast period. In February 2020, the U.S. Food and Drug Administration approved the Palforzia drug (available in an encapsulated form), which is designed in a way that eliminates the risk of severe peanut-induced allergic reactions through desensitization.
Generally, vegetarian capsules are made of hypromellose, a polymer formulated from cellulose and other polysaccharides like pullulan (a polysaccharide polymer consisting of maltotriose units) and starch. These capsules are separated into two halves – a lower-diameter ‘body’, which is filled and then sealed using a higher-diameter ‘cap’.
Global Empty Capsules Market Dynamics:
Generally, vegetarian capsules are made of hypromellose, a polymer formulated from cellulose and other polysaccharides like pullulan (a polysaccharide polymer consisting of maltotriose units) and starch. These capsules are separated into two halves – a lower-diameter ‘body’, which is filled and then sealed using a higher-diameter ‘cap’
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Oxygen permeability is a prominent factor that varies in different commercially used capsule shell ingredients. Therefore, the HPMC capsule shells are used for the formulation of moisture-sensitive APIs. No research-based evidence exists for this proposed benefit of HPMC capsule shells, which is a growth-propelling factor for the global market.
However, the deteriorating standards of capsules, in terms of purity and reliability, have resulted in high customer dissatisfaction in the recent times. This can be attributed to the technical issues caused during the manufacture of empty capsules, for example, improper drying of capsules that causes color spotting. Other manufacturing issues include improper usage of gelatin tissue with specified risk materials, usage of artificial colorants for coating, high disintegration & dissolution rates with gelatin capsules, and inappropriate labelling of the capsules. Hence, such factors pose a significant threat to the growth of the global empty capsules over the forecast period.
Market Analysis:
The global empty capsules market observes a high adoption rate of cellulose-based capsules, which are known to offer several physiological properties, such as low moisture content. Such properties are best suited for hygroscopic drugs and nutritional supplements. Moreover, the demand for halal-certified capsules has risen up immensely, which has prompted manufacturers to provide their products with halal and Kosher certifications.
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The vegetarian-based capsules segment was valued at US$ 533.3 million in 2019, and is expected to reach US$ 1,228.0 million by 2027. Increasing demand for vegetable/non-gelatin capsules, which is triggered by the growing preference for organic products, majorly propels the growth of this segment.
Furthermore, the oral administration segment led the global empty capsules market in 2019, accounting for a whopping 90.3% market share, in terms of value. Increasing approvals and launches of oral drugs and medications in the capsule form boosts the segmental growth.
Stringent Regulations:
North America;
• The U.S. FDA inspects empty capsule manufacture units for compliance of cGMP guidelines.
• FDA strictly guides to gelatin capsules manufacturers about sourcing and processing of gelatin to reduce the potential risk posed by bovine spongiform encephalopathy (BSE).
Competitive Landscape:
The established players operating in the global empty capsules market include ACG Group, Capsugel (Lonza Group AG), Qualicaps, Inc., Bright Pharma Caps, Inc., Sunil Healthcare Ltd., CapsCanada Corporation, Roxlor LLC, Snail Pharma Industry Co., Ltd., Suheung Co., Ltd., and Medi-Caps Ltd.
In November 2019, Qualicaps, Inc. presented its products and service offerings for the hard-capsule dosage form at the CPHI WORLDWIDE 2019 conference. In February 2018, CapsCanada Corporation announced the addition of a new, state-of-the-art, dedicated hydroxypropyl methylcellulose (HPMC) capsule manufacturing facility.
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