Across the world, the lifestyle is becoming increasingly sedentary and fast paced. While sitting on a chair in offices all day leads to physical inactivity, the fast pace of life results in emotional stress. With lack of time, people’s dietary pattern gets affected, which leads to improper nutrition. All these factors, combined with tobacco and alcohol abuse, result in chronic diseases, such as diabetes, chronic obstructive pulmonary disease (COPD), cancer, and several cardiovascular diseases (CVD), the prevalence of all of which is rising. As per the World Health Organization, the number of diabetics rose to 422 million in 2014, from 108 million in 1980.

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Transdermal drug delivery systems are used for analgesics (pain relief), hormone replacement, smoking cessation, hypertension, and motion sickness. Among these, the widest usage of such devices has been for pain relief, as pain is the most commonly seen symptom of any health issue, and it can often be so much that it affects people’s ability to make rational decisions. Most of the chronic diseases, especially CVDs and cancer, have pain as a symptom, which is the reason behind the heavy consumption of painkillers, via the skin.

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The Centers for Disease Control and Prevention (CDC) estimated the number of new cancer cases in the U.S., for 2018 at 1,735,350. The agency also says that in the country, 805,000 people suffer from a heart attack, which often causes chest pain, during the attack and long after it is over. Apart from diseases and emotional stimulus, the gradual weakening of the body, which happens with age, results in several musculoskeletal issues, such as arthritis, atrophy, and frequent fractures. As all of these cause pain, the elderly require constant analgesics dosage.