Zirconia (ZrO2) is really a ceramic material with sufficient mechanical properties for manufacturing of healthcare devices. Zirconia stabilized with Y2O3 has the most effective properties for these applications. When a pressure happens on a ZrO2 surface, a crystalline modification opposes the propagation of cracks. Compression resistance of ZrO2 is about 2000 MPa. Orthopedic study led to this material becoming proposed for the manufacture of hip head prostheses. Before this, zirconia biocompatibility had been studied in vivo; no adverse responses had been reported following the insertion of ZrO2 samples into bone or muscle. In vitro experimentation showed absence of mutations and very good viability of cells cultured on this material. Zirconia cores for fixed partial dentures (FPD) on anterior and posterior teeth and on implants are now out there. Clinical evaluation of abutments and periodontal tissue have to be performed before their use. Zirconia opacity is extremely useful in adverse clinical situations, for example, for masking of dischromic abutment teeth. Radiopacity can aid evaluation through radiographic controls. Zirconia frameworks are realized by utilizing computer-aided design/manufacturing (CAD/CAM) technology. Cementation of Zr-ceramic restorations might be performed with adhesive luting. Mechanical properties of zirconium oxide FPDs have proved superior to these of other metal-free restorations. Clinical evaluations, which happen to be ongoing for three years, indicate a fantastic results price for zirconia FPDs. Zirconia implant abutments also can be utilized to improve the aesthetic outcome of implant-supported rehabilitations. Newly proposed zirconia implants appear to possess fantastic biological and mechanical properties; additional research are necessary to validate their application.