It is generally accepted that the regulation of muscle tissue is carried out, at least in part, through the signaling of various pathways associated with protein synthesis and breakdown. These pathways are diverse and provide a variety of ways for muscle to adapt to overload. The common element of all muscle-building pathways is that they conduct signals through specialized enzymes, setting off a chain of events that ultimately promote protein synthesis and inhibit protein breakdown.

Gymgoers who abuse Crazy Bulk and similar supplements also have increased risks of other health problems such as body dysmorphic disorder, a condition previously referred to as reverse anorexia. The researchers likewise found that the participants who inappropriately used dietary supplements have increased odds for behaviors associated with eating disorders.