When I first played Path of Exile, I was confused about all aspects of the game and I know that some useful guides are important to many players. Today, I will give you some general advice during Storyline in PoE.

1. Keep your flasks updated. I recommend 2x Life Flasks, 1x Mana Flask and 2x Quicksilver Flasks, switch one Life Flask with a Basalt Flask of Staunching in early Act 7. You can find a list of all flasks here.

2. Upgrade your gear. While not as relevant in the beginning, it's important to look out for gear with solid life and resistance rolls. Ideally you want to have all three Elemental Resistances capped at 75% at the end of Act 3, only Chaos Resistance may be at whatever value.

3. Rare or Unique gear pieces are not always the best for this purpose, sometimes you're better off with Magic gear giving life and a single resistance.

4. You can easily craft your own gear, ideally on already 4-linked pieces you get from vendors or drops, however only use Orbs of Transmutation/Augmentation/Alteration at this point, everything else is a huge waste!

5. If you happen to get a 5-linked, or even 6-linked Intelligence-based gearpiece, check the damage skill setups in the gem section to know what gems to add.

6. Great Uniques for leveling are Lifesprig, Reverberation Rod, Amplification Rod, Crest of Perandus, Goldrim, Wanderlust and Tabula Rasa, but prioritize a good lifepool and capped resistances!

7. Use Portal Scrolls and enter town to refill flasks during bossfights.

8. Get all waypoints you can find. I mention specific waypoints you will definitely need, but generally it's recommended to get them all, since you never know if you may disconnect or need to get back to that zone for other reasons.

9. If there's multiple gems listed to get, it means you're supposed to get one of those as quest reward and buy the rest from the gem vendor in town.

10. The passive tree goals for each act are just a pointer, if you're short by 1-2 points or overleveled that's not a big deal.

There's a lot more players guide on U4GM, so be sure to check out if you need some guides.